The ULTIMATE blood concentrate just got even better!
EZGEL is a 100% autologous and natural gel material, obtained through centrifugation of a whole blood sample to isolate beneficial cells, then subjected to a cooling and heating process, without any chemical addition nor modification.
By heating up Plasma, particularly HSA, we're modifying its rheological properties. Temperature variation is the most natural way to create an intermolecular bond, without using any additives such as BDDE for cross linking.
EZGEL is created by combining this heated plasma gel and EZPRF concentrate at a 2:1 ratio.
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Shaped very much like a heart, serum albumins are the most abundant proteins in blood, constituting nearly 60% of blood plasma proteins.
This is the star protein of our new protocol. We'll illustrate denaturation and take a deep look at this protein's reaction to temperature (Unfolding).
But first, let's refresh our memory on some of the key definitions.
When a protein starts to lose it's biomolecular structure. Denaturation of proteins is a process of transition from the folded to the unfolded state.
Denaturation is reversible under a certain temperature / stress. We prefer "unfolding" and "refolding" up until it's irreversible because it's a very visual term. (see next section)
Forming a cluster of things that have come together.
Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure or pattern.
The protein melting point (TM) is defined as the temperature at which the protein denatures.
A folded protein is just like a folded paper clip! In their folded state, they can be moved around and won't get tangled.
Our folded proteins flow freely in their fluid vehicle / environment (The plasma).
Once unfolded, paper clips start aggregating and assemble in an organized structure
This is also called self-assembly of proteins.
The temperature behavior of Albumin has been studied for over 50 years. Many articles can be found online, here's a quick recap:
Conclusion: at 75°C, our proteins' self-assembly is irreversible, but we haven't overcooked them.
* 75°C = 167°F
We're working longevity studies, but for now here are several studies on the unfolding of HSA:
Kian Karimi MD, FACS, and Anil Rajani, MD. Cindy J. Papp, Contributing Editor
Rolf WETZEL, Manfred BECKER, Joachim BEHLKE, Heidi BILLWITZ, Siegfried BOHM, Bernd EBERT, Harald HAMANN, Johannes KRUMBIEGEL, and Giinter LASSMANN
KNUT WALLEVIK - From the Department of Chemistry, University of Oregon, Eugene, Oregon 97403, and The Finsen Laboratory, The Finsen Institute, Copenhagen, Denmark
Nirmal Kumar Das, Narayani Ghosh, Ajit Prabhakar Kale, Ramakanta Mondal, Uttam Anand, Subhadip Ghosh, Virendra Kumar Tiwari, Manmohan Kapur, and Saptarshi Mukherjee
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